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MTHF Folate

Bioavailable folate supplement


A biologically active methylated folate supplement for reproductive health and fetal development. 

Our 5 MTHF supplement contains the most abundant form of folate found in the body. Folate is recommended by the CDC and ACOG for all women of childbearing age to reduce the risk of spina bifida and other neural tube defects. Each tablet contains 1,000 mcg (1 mg) of folate to support fertility and pregnancy outcomes.‡

Bundle & save $15 with our Trimester Pack: Prenatal Daily Packets.

Why We're Proud

GMP Certified

Evidence Backed


Gluten Free

100% Plastic Neutral

No Preservatives

Dr. Gaskins

"I've spent a big part of my career studying the impact of nutrition on fertility, and my top recommendation for women trying to conceive is to take at least 800 mcg of folate daily."

MTHF Folate for fertility and pregnancy

Helps fight environmental toxins

Helps fight environmental toxins

Research from two independent studies suggest that high doses of methylfolate supplementation can help the body reduce the negative effects of environmental pollutants on fertility.‡

Promotes healthy fertility

Promotes healthy fertility

Higher intakes of MTHF Folate have been correlated with a reduced risk of infertility, shorter time to pregnancy, lower risk of pregnancy loss, and better outcomes of fertility treatments.‡

Promotes healthy spine development

Promotes healthy spine development

The CDC recommends that women consume 0.4 mg of folic acid per day to reduce the risk of having a pregnancy affected with spina bifida or other neural tube defects. Our MTHF Folate exceeds this.‡

May help IVF success rate

May help IVF success rate

A 2019 Harvard study found that women who took in more than 800 micrograms (mcg) of supplemental folate while undergoing fertility treatment, among other dietary changes, had an increased probability of live birth.‡

We do our homework. See the research behind our Methylated Folate (MTHF) supplements.

Technical Information

MTHF Folate Usage

Adults take 1 tablet every day or as directed by your doctor.

Serving Size: 1 Tablet

Servings Per Container: 60


Folate (as Metafolin®) 1,667 mcg DFE (1000 mcg L-5-MTHF)

Other ingredients:

Dicalcium Phosphate, Silicon Dioxide, Stearic Acid, Croscarmellose Sodium, Microcrystalline Cellulose, Magnesium Stearate.

Commonly asked questions about Natalist's MTHF Folate

Is your MTHF gluten-free?


Is your MTHF GMO-free?

Yes, our MTHF Folate is non-GMO. 

How should I take MTHF?

That is totally up to you. Some people find it most convenient to take all of their vitamins for the day together; others prefer to space them out. Some take them in the morning; some take them at night. Some take them with food; others don’t. Experiment and find what works best for you.

Will MTHF make me nauseous?

It’s possible, but unlikely. If they do, try taking them with food or before bed to lessen this effect. 

How should I store my MTHF?

For optimal results, vitamins should be stored in a cool, dry place. Avoid placing your vitamins in areas with excess heat or moisture; these elements can start to deteriorate the product and reduce their potency. 

Does your MTHF Folate contain folate or folic acid?

Our product utilizes Folate in the natural form of 5-MTHF. For information on MTHF folate, read here

What is the difference between Methylated Folate and Folic Acid?

While the terms are sometimes used interchangeably, folic acid is a synthetic form of folate made in a laboratory. It’s found in vitamins, and it is also used in fortification of some processed foods. Methylated folate is dietary folate that can also be found in prenatal vitamins. It’s a bit confusing, but MTHF folate can go by many names, such as levomefolic acid, L-5-MTHF, L-5-methyltetrahydrofolate, and (6S)-5-methyltetrahydrofolate, (6S)-5-MTHF. They are all the same kind of folate. Folic and folate are both within prenatal supplements, but you can read more on if folate or folic acid is better for prenatal vitamins.

Can I take this while pregnant or breastfeeding?

Yes. You can take MTHF Folate while breastfeeding, however, we recommend you consult your doctor if you have any concerns. 

Do these expire?

Yes, all good things must come to an end. Check the expiration date on the bottle. 

What if I take too many vitamins?

Call poison control at 800-222-1222.

How big is the Natalist MTHF?

Our MTHF Folate is a tablet that is 11/32” round.

What is this bottle made of?

Our supplement bottles are made of HDPE plastic (#2), BPA and phalate free, and are blue-bin recyclable. 

So, why should you take 5 Methylfolate when trying to conceive?

Simply put, it’s the perfect supplement that promotes healthy fertility because it can both increase the chance of a healthy fetus and can help strengthen your reproductive system.

What makes your packaging earth friendlier?

All Natalist products and packaging are 100% plastic neutral. For every pound of plastic we sell, we facilitate the removal of a pound of plastic pollution—giving your purchase a net-zero plastic footprint.

Can I get just one month's worth of MTHF Folate?

Consistency is key for many supplements, so we only offer this product as a subscription purchase. If you want to try it just once, you can place an order and either skip the next shipment, choose a specific date for your next shipment, or cancel. Simply log in to your Natalist account, head over to “Manage Subscriptions,” and click “Edit” to get started. Additionally, we are excited to offer exclusive perks to subscribers, including discounted products (up to 50% off) and free shipping on all subscription orders.

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‡These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Consult your healthcare provider before adding any supplements to your regimen.