MTHF Folate
MTHF Folate
A biologically active methylated folate supplement for reproductive health and fetal development.
Our 5-MTHF supplement contains the most abundant form of folate found in the body. Folic acid, which the body metabolizes into 5-MTHF, is recommended by the CDC and ACOG for all women of childbearing age to reduce the risk of spina bifida and other neural tube defects. Each tablet contains 1,000 mcg (1 mg) of folate to support reproductive health and fetal development.‡
Product Details
- 2 month supply: 60 vegan tablets
- 1,000 mcg (1 mg) folate per tablet
- Contains no yeast, wheat, gluten, soy protein, dairy, corn, sodium, sugar, starch, artificial coloring, preservatives, or flavoring
Why We're Proud
GMP Certified
Evidence Backed
Vegan
Gluten Free
100% Plastic Neutral
No Preservatives
We do our homework. See the research behind our Methylated Folate (MTHF) supplements.
Natalist vitamins and supplements are formulated with attention to detail. Each ingredient is researched and considered.
Natalist vitamins and supplements are formulated with premium, high bioavailability ingredients for maximum efficacy and potency.‡
We are committed to manufacturing excellence. Every batch of vitamins and supplements is tested for product integrity.
All of our vitamins are made in an FDA Registered and Inspected Facility, which meets or exceeds FDA 21 CFR 111 guidelines. Certificates of analysis are reported for every batch of manufactured vitamins to ensure final product integrity and quality. Our vitamins are free of artificial and synthetic dyes and all allergens are disclosed on our label. Additionally, our vitamins are manufactured under strict procedures to ensure there is no cross-contamination during manufacturing and storage.‡
Formulated with high bioavailability MTHF folate to help protect against neural tube defects.
MTHF folate (L-5-MTHF) is the most abundant folate found in the human body. It is naturally found in food, but is most easily absorbed from a dietary supplement. MTHF folate is the highest bioavailability folate found in dietary supplements. It can be immediately utilized by your body and doesn’t need to be converted by the enzyme methylenetetrahydrofolate reductase (MTHFR).
Non-GMO, but that doesn’t really matter.
Along with 88% of polled scientists, Natalist believes that the majority of genetically modified (GM) foods are safe. That said, we also believe that bioengineered ingredients should be clearly labeled so that consumers can make an informed purchase decision. Transparency is essential in building trust between brands and consumers. Our products clearly state if they do or do not contain genetically modified organisms (GMOs).
Discuss your dietary supplement routine with your doctor.
There’s a lot of junk science out there, and products being sold with grand promises, but little or no data to back it up. We stand by our products and only sell supplements with ample clinical evidence supporting the claims. We try to be very clear about who would benefit most from these supplements, but it’s also important to discuss your dietary supplement routine with your physician who can give further guidance.
ALLERGEN WARNING:
This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish, and crustacean shellfish.
Here's some of the research that went into making our MTHF Folate supplement.
Cetin, I., C. Berti, and S. Calabrese. 2010. “Role of Micronutrients in the Periconceptional Period.” Human Reproduction Update 16 (1): 80–95.
Gaskins, Audrey J., Myriam C. Afeiche, Diane L. Wright, Thomas L. Toth, Paige L. Williams, Matthew W. Gillman, Russ Hauser, and Jorge E. Chavarro. 2014. “Dietary Folate and Reproductive Success among Women Undergoing Assisted Reproduction.” Obstetrics and Gynecology 124 (4): 801–9.
Gaskins, Audrey J., and Jorge E. Chavarro. 2018. “Diet and Fertility: A Review.” American Journal of Obstetrics and Gynecology 218 (4): 379–89.
Gaskins, Audrey J., Yu-Han Chiu, Paige L. Williams, Jennifer B. Ford, Thomas L. Toth, Russ Hauser, Jorge E. Chavarro, and EARTH Study Team. 2015. “Association between Serum Folate and Vitamin B-12 and Outcomes of Assisted Reproductive Technologies.” The American Journal of Clinical Nutrition 102 (4): 943–50.
Gaskins, Audrey J., Lidia Mínguez-Alarcón, Kelvin C. Fong, Yara Abu Awad, Qian Di, Jorge E. Chavarro, Jennifer B. Ford, et al. 2019. “Supplemental Folate and the Relationship Between Traffic-Related Air Pollution and Livebirth Among Women Undergoing Assisted Reproduction.” American Journal of Epidemiology 188 (9): 1595–1604.
Put, N. M. van der, H. W. van Straaten, F. J. Trijbels, and H. J. Blom. 2001. “Folate, Homocysteine and Neural Tube Defects: An Overview.” Experimental Biology and Medicine 226 (4): 243–70.
Technical Information
Why might you consider taking 5-MTHF when trying to conceive? Simply put, it can help support healthy fetal development.
MTHF Folate Usage
Adults take 1 tablet every day or as directed by your healthcare provider.
Serving Size: 1 Tablet
Servings Per Container: 60
Ingredients
Other ingredients:
Commonly asked questions about Natalist's MTHF Folate
Is your MTHF gluten-free?
Yes!
Is your MTHF GMO-free?
Yes, our MTHF Folate is non-GMO.
How should I take MTHF?
That is totally up to you. Some people find it most convenient to take all of their vitamins for the day together; others prefer to space them out. Some take them in the morning; some take them at night. Some take them with food; others don’t. Experiment and find what works best for you.
We always recommend connecting with your personal healthcare provider before making any changes to your vitamin and supplement routine.
Will MTHF make me nauseous?
It’s possible, but unlikely. If they do, try taking them with food or before bed to lessen this effect.
How should I store my MTHF?
For optimal results, vitamins should be stored in a cool, dry place. Avoid placing your vitamins in areas with excess heat or moisture; these elements can start to deteriorate the product and reduce their potency.
Does your MTHF Folate contain folate or folic acid?
Our product utilizes folate in the natural form of 5-MTHF. For information on MTHF folate, read here.
What is the difference between Methylated Folate and Folic Acid?
Can I take this while pregnant or breastfeeding?
Yes. You can take MTHF Folate while breastfeeding, however, we always recommend connecting with your healthcare provider prior to making any changes to your vitamin and supplement routine.
Do these expire?
Yes, all good things must come to an end. Check the expiration date on the bottle.
What if I take too many vitamins?
Call poison control at 800-222-1222.
How big is the Natalist MTHF?
Our MTHF Folate is a tablet that is 11/32” round.
What is this bottle made of?
Our supplement bottles are made of HDPE plastic (#2), BPA and phalate free, and are blue-bin recyclable.
So, why should you take 5 Methylfolate when trying to conceive?
Simply put, it can help support healthy fetal development.
What makes your packaging earth friendlier?
All Natalist products and packaging are 100% plastic neutral. For every pound of plastic we sell, we facilitate the removal of a pound of plastic pollution—giving your purchase a net-zero plastic footprint.
Consult your healthcare provider before adding any supplements to your regimen.