Natalist vitamins are formulated with premium, high bioavailability ingredients for maximum efficacy and potency.‡

All our fertility vitamins are made in an ISO/IEC 17025:2005 certified facility, which exceeds the FDA cGMP (Good Manufacturing Practices) manufacturing standards (21 CFR 111). Certificates of analysis are reported for every batch of manufactured vitamin to ensure final product integrity and quality. Our vitamins are free of artificial and synthetic dyes and all allergens are disclosed on our label. Additionally, our vitamins are manufactured under strict procedures to ensure there is no cross-contamination during manufacturing and storage.‡

In a 2020 systematic review and meta-analysis of 46 trials with 6,312 women, ten adjuvant treatments for poor ovarian response in IVF were evaluated. Compared with controls, CoQ10 treatments resulted in a “significantly higher chance” of clinical pregnancy. Additionally, CoQ10 supplementation led to the lowest cancelation rates for IVF cycles. The authors conclude that, for women with poor ovarian response, controlled ovarian stimulation protocols including CoQ10 showed better clinical outcomes.^‡

Female fertility typically declines after the age of 35. This decline is primarily due to an age-related decrease in egg quality that typically occurs in many women. In the aging process, CoQ10 concentration in parts of the body (including female eggs) declines. Therefore, some fertility doctors recommend CoQ10 supplementation for women over 35 to make up for the natural decline that may contribute to decreased egg quality. 

The data on CoQ10 is emerging, and there haven’t been randomized double-blind clinical trials focusing on female fertility yet. Studies that have been conducted so far suggest that, in women over 35, supplementing with CoQ10 may lead to improved egg quality, improved embryo quality, and improved pregnancy outcomes. Another 2017 study concluded that higher CoQ10 levels in follicular fluid (fluid that surrounds the ovum in the ovary) are associated with higher pregnancy rates. 

And data from a small 2018 study suggests that supplementation with CoQ10 resulted in improved egg quality, especially in women over 35 years of age.

However, it’s important to note that other studies have shown low-quality evidence on the benefits of antioxidants for infertility.^‡

CoQ10 is an antioxidant found in almost all cells in our bodies. Antioxidants help the body combat free radicals, which are unstable molecules that easily react and damage other molecules in the cell. If you have too many reactive oxygen species in your body, and not enough antioxidants to neutralize them, it can lead to damage to various tissues, including your eggs. This oxidative damage may result in reduced egg quality in some cases, which can lead to fertility challenges.^‡

Poor sperm motility means that the sperm do not swim properly and may not be able to reach the egg. Sperm is extremely susceptible to oxidative stress, which can cause sperm damage. Antioxidants combat oxidative stress. Since CoQ10 is a potent antioxidant, it has been shown in clinical trials to evaluate its potential role in improving male fertility parameters like improving sperm motility.

In a meta-analysis published in 2018, researchers concluded that CoQ10 supplementation resulted in better sperm motility along with improved sperm concentrations and sperm count.

As always, we recommend the fellas discuss supplement routines with their physician who can give further guidance.^‡

Guidelines from the American Academy of Neurology and the American Headache Society say that CoQ10 is possibly effective in preventing migraines.

In a meta-analysis consisting of five studies with 346 patients, CoQ10 was more effective than placebo in reducing migraine days/month and migraine duration.^‡

Along with 88% of polled scientists, Natalist believes that the majority of genetically modified (GM) foods are safe. That said, we also believe that bioengineered ingredients should be clearly labeled so that consumers can make an informed purchase decision. Transparency is essential in building trust between brands and consumers. Our products clearly state if they do or do not contain genetically modified organisms (GMOs).

Even though a supplement is natural doesn’t automatically mean that it is safe and without any risk. Thankfully, researchers evaluated the safety of supplementing with CoQ10 and found that, after reviewing published reports, CoQ10 is “highly safe for use as a dietary supplement.” In fact, we recommend pairing our CoQ10 capsules with a daily prenatal multivitamin for a more comprehensive prenatal routine. Of course, we encourage you to check with your doctor before you start this, or any supplemental regimen to make sure it meets your personal needs.

There’s a lot of junk science out there, and products being sold with grand promises, but little or no data to back it up. We stand by our products and only sell fertility supplements with ample clinical evidence supporting the claims. We try to be very clear about who would benefit most from these supplements, but it’s also important to discuss your prenatal supplement routine with your physician who can give further guidance.

This product is manufactured and processed in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish, and crustacean shellfish.

Ben-Meir, Assaf, Eliezer Burstein, Aluet Borrego-Alvarez, Jasmine Chong, Ellen Wong, Tetyana Yavorska, Taline Naranian, et al. 2015. “Coenzyme Q10 Restores Oocyte Mitochondrial Function and Fertility during Reproductive Aging.” Aging Cell 14 (5): 887–95.

Bentov, Yaakov, and Robert F. Casper. 2013. “The Aging Oocyte--Can Mitochondrial Function Be Improved?” Fertility and Sterility 99 (1): 18–22.

Bentov, Yaakov, Thomas Hannam, Andrea Jurisicova, Navid Esfandiari, and Robert F. Casper. 2014. “Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment.” Clinical Medicine Insights. Reproductive Health 8 (June): 31–36.

El Refaeey, Abdelaziz, Amal Selem, and Ahmed Badawy. 2014. “Combined Coenzyme Q10 and Clomiphene Citrate for Ovulation Induction in Clomiphene-Citrate-Resistant Polycystic Ovary Syndrome.” Reproductive Biomedicine Online 29 (1): 119–24.

Giannubilo, Stefano Raffaele, Patrick Orlando, Sonia Silvestri, Ilenia Cirilli, Fabio Marcheggiani, Andrea Ciavattini, and Luca Tiano. 2018. “CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity.” Antioxidants (Basel, Switzerland) 7 (10). https://doi.org/10.3390/antiox7100141.

Showell, Marian G., Rebecca Mackenzie-Proctor, Vanessa Jordan, and Roger J. Hart. 2017. “Antioxidants for Female Subfertility.” Cochrane Database of Systematic Reviews 7 (July): CD007807.

Xu, Yangying, Victoria Nisenblat, Cuiling Lu, Rong Li, Jie Qiao, Xiumei Zhen, and Shuyu Wang. 2018. “Pretreatment with Coenzyme Q10 Improves Ovarian Response and Embryo Quality in Low-Prognosis Young Women with Decreased Ovarian Reserve: A Randomized Controlled Trial.” Reproductive Biology and Endocrinology: RB&E 16 (1): 29.