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Methylfolate Supplementation for Fertility and Pregnancy

Apr 11, 21 4 min
Methylfolate Supplementation for Fertility and Pregnancy - Natalist

OBGYN Dr. Kenosha Gleaton explains how folate supplementation can be beneficial for fertility, fertility treatment outcomes, and pregnancy.

By OBGYN Dr. Kenosha Gleaton

Folate, also known as vitamin B9, is an essential vitamin with important implications relating to pregnancy and pregnancy loss. However, a less commonly known fact is that folate also plays a key role in fertility and the health of newborns and infants. 

What is methylfolate? 

Methylfolate is the form of folate that is active in the body for use. This methylated form of folate is what is required for the body to benefit from folate. Unfortunately, up to 60% of the population carry a gene mutation that does not allow for proper conversion of folic acid to this active form of methylfolate which can lead to folate deficiencies.

Folate inadequacy and deficiency

Due to the high frequency of the MTHFR gene mutation, many women are folate deficient with levels less than recommended. Folate deficiency can also develop as a result of a diet that's low in folate containing foods including dark green vegetables, citrus juices and foods. 

In addition, folate deficiency can be difficult to detect because symptoms are usually nonspecific, but include mouth sores, tongue swelling, fatigue, and gray hair.

Does my prenatal have enough folate? 

When selecting a prenatal vitamin, it's necessary to select one that contains the right kind and the right amount of folate. Natalist’s Prenatal is made with 5-MTHF, the naturally occurring, predominant form of folate found in the body. Folate is recommended by the CDC and ACOG for all women of childbearing age to reduce the risk of spina bifida and other neural tube defects. ACOG specifically recommends that pregnant women get 600 micrograms of folic acid each day. Because it’s hard to get this much folic acid from food alone, women should take a daily prenatal vitamin with at least 400 micrograms starting at least one month before pregnancy and continue during pregnancy for at least the first 12 weeks. 

✨ Shop Prenatal Daily Packets⟶

How do I know if I need more folate? 

There are certain circumstances that warrant increased amounts of folate including a history of miscarriages, history of a child with a neural tube defect, and those taking antiseizure medications. Ask your OBGYN provider if additional folate supplementation is right for you. 

Women who have had a child with an NTD should take four milligrams (mg) of folic acid each day as a separate supplement at least three months before pregnancy and for the first three months of pregnancy. You and your OBGYN or other obstetric care provider can discuss whether you need to supplement with more than 400 micrograms daily.

Does folic acid help increase the chances of getting pregnant?

In addition to prevention of birth defects and pregnancy loss, a daily multivitamin that contains folate before and during pregnancy may not only prevent birth defects, but also improve the chance of achieving and maintaining a pregnancy.

Does folate help with IVF?

If a woman is undergoing IVF, I recommend that she take over 800 mcg of supplemental folate. This is based off of a study suggesting a relationship between supplementation of certain micronutrients and higher chance of IVF success. One of these micronutrients is folic acid (folate) and taking in at least 833 mcg appears to offer some benefit. In addition, there is evidence demonstrating that high folate supplementation (> 800ug) might protect against the adverse reproductive consequences of traffic-related air pollution.

Health risks from too much folate

While folate offers many benefits, there can be risks of consuming too much. According to the National Institutes of Health (NIH), the daily upper limit for folate from supplements and fortified foods and beverages for adults 19 years and older is 1,000 mcg. Excessive folate supplementation can cause neural development issues in children, cognitive decline in adults, and can cause recurrence of cancer in those with a personal history of cancer.

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Folate has many benefits

Folate is a B vitamin which has many benefits for both mom and baby including improved fertility outcomes, decreased miscarriage rates, and reduction of birth defects (mainly neural tube defects). All forms of folic acid are not readily absorbed or utilized by the body, so it's important to seek out the highly bioavailable methylfolate—like what's found in Natalist Prenatal Daily Packets.

 

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